XIAPEX® (Collagenase clostridium histolyticum)

A non-surgical treatment for Dupuytren's contracture for adults

Dupuytren's disease is a condition which affects the tissue in the palm of the hand and the fingers causing one or more fingers to become permanently bent inward (Dupuytren's contracture). The condition is common, especially among white Europeans. More men than women have the condition, which often occurs later in life. It is estimated to affect up to 20% of men over 60 years of age, and 20% of women over 80. Treatment is required if the normal function of the hand is affected.

The treatment procedure

XIAPEX® consists of enzymes called collagenases, which break down the cord. It is injected directly into the cord under the skin. On the following day, manipulation breaks the cord freeing the digit.

XIAPEX® is the first medicine licensed for adults with Dupuytren's contracture. Treatment must be undertaken by a specialist consultant and can be performed as a day case involving 2 short visits on concurrent days.


No need for surgery – digital or palmar fasciectomy.
Reduced recovery time – from weeks to days
Ideal for surgery averse patients

Q & A:

Q. Can a GP perform the procedure?
A. Only consultants with specialism in orthopaedics can perform this treatment.
Q. Is physiotherapy required after XIAPEX?
A. Yes - daily finger exercises.
Q. What if both hands are affected?
A. XIAPEX® treatment should be performed on one cord at a time.
Q. Where can I find more information about Dupuytren's disease?
A. At the NHS Choices website: http://www.nhs.uk/conditions/Dupuytrens-contracture